Adverse Effects and Drug Interactions
The use of peppermint as a medicinal herb has been generally safe and non-toxic at therapeutic doses. However, at high enough concentrations, there have been reports of adverse reactions, as well as adverse drug interactions. When peppermint is administered orally at high concentrations, mucosal tissues may become irritated to the extent that a contact dermatitis develops (Magee, 2005). Peppermint can also potentially become an irritant and provoke hypersensitivity or allergic reactions (Spirling & Daniels, 2001). If taken in the form of a non enteric-coated capsule, heartburn and oesophageal discomfort may result (Spirling & Daniels, 2001).
Other common adverse reactions include blurred vision, vomiting, and nausea (Kligler & Chaudhary, 2007). In recent studies, it has been hypothesized that peppermint oil may have an effect on the metabolism of drugs in the body by inhibiting the cytochrome P450 1A2 system (Kligler & Chaudhary, 2007). As a result, there will be increased serum levels of drugs metabolized by this system. As with many other medicinal products, peppermint oil is not recommended for use in very young children or pregnant women (Kligler & Chaudhary, 2007).
The use of peppermint as a medicinal herb has been generally safe and non-toxic at therapeutic doses. However, at high enough concentrations, there have been reports of adverse reactions, as well as adverse drug interactions. When peppermint is administered orally at high concentrations, mucosal tissues may become irritated to the extent that a contact dermatitis develops (Magee, 2005). Peppermint can also potentially become an irritant and provoke hypersensitivity or allergic reactions (Spirling & Daniels, 2001). If taken in the form of a non enteric-coated capsule, heartburn and oesophageal discomfort may result (Spirling & Daniels, 2001).
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| (Magee, 2005) |
Other common adverse reactions include blurred vision, vomiting, and nausea (Kligler & Chaudhary, 2007). In recent studies, it has been hypothesized that peppermint oil may have an effect on the metabolism of drugs in the body by inhibiting the cytochrome P450 1A2 system (Kligler & Chaudhary, 2007). As a result, there will be increased serum levels of drugs metabolized by this system. As with many other medicinal products, peppermint oil is not recommended for use in very young children or pregnant women (Kligler & Chaudhary, 2007).
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